Non-Surgical Hair Treatments: PRP and Mesotherapy Applications
Hair loss is a multifactorial aesthetic and medical issue that directly affects an individual's quality of life, social perception, and self-confidence. Genetic predisposition (Androgenetic Alopecia), chronic stress management, hormonal fluctuations, micronutrient deficiencies, and environmental factors shorten the life cycle of hair follicles, leading to thinning and loss. The discipline of plastic surgery approaches this process not merely as a loss of appearance, but as an issue of cellular regeneration and tissue quality. Modern aesthetic surgery now encompasses not only the surgical replacement of losses but also the preservation and revitalization of existing tissue health at the molecular level.
The non-surgical hair treatments offered in our clinic are professional interventions that preserve existing hair, optimize follicular unit health, and control the rate of loss using scientific methods, rather than being an alternative to hair transplant procedures. Our specialized focus is to maximize the biological potential of the scalp through non-surgical methods. With this approach, we aim to extend the lifespan of hair follicles and postpone or completely eliminate the stage where surgical intervention (hair transplant) would be necessary. Our treatment protocols are evidence-based medical practices personalized according to the patient's hair analysis.
Important Information: Surgical hair transplant operations are not performed within our clinic. Our expertise is focused on professional injection therapies (PRP and Mesotherapy) aimed at saving and strengthening existing hair follicles and biologically restoring scalp health. This focus allows us to offer our patients the highest success rates in non-surgical methods.
Scalp Anatomy and the Role of Plastic Surgery Expertise
The scalp has a much denser vascular network and a complex nervous system structure compared to other parts of the body. A strand of hair is not just a keratin structure visible on the skin; it is a living micro-organ directly related to stem cell pools located in the dermis layer of the skin, approximately 3 to 5 millimeters deep, known as the "bulge" region. Full mastery of the anatomical structure and layers of this region is the most fundamental criterion determining the success of applied medical treatments. Plastic surgery training is built upon the ability to make millimetric distinctions between tissue layers.
Hair treatments performed by a Plastic Surgery Specialist ensure that the injection reaches exactly the correct tissue layer where the follicle is nourished and cell division is triggered. Applications performed at incorrect depths can lower bioavailability and cause unnecessary edema or micro-trauma in the tissue. All processes in our clinic are managed with this deep surgical mastery of skin anatomy, medical sterilization, and sensitivity toward tissue biology. The success of the treatment depends as much on the quality of the material used as it does on the practitioner's ability to recognize and manipulate tissue layers.
Our clinical experience shows that hair treatments are not just an "injection" procedure but require a tissue engineering approach. The health of the capillary vessels nourishing the hair follicle is directly related to the vasodilation effect of the biological materials used (PRP plasma or Mesotherapy cocktail) on these vessels. Therefore, planning carried out under specialist supervision secures not only the patient's today but also their future hair health.
Hair PRP (Platelet Rich Plasma) Treatment and Regenerative Processes
PRP treatment is one of the most successful applications of modern regenerative medicine, based on utilizing the natural healing power within the patient's own blood. This method involves applying plasma, obtained by concentrating "platelet" cells found in the blood 4 to 8 times more than their normal concentration, to the scalp. Platelets do not only provide blood clotting; they also contain Growth Factors necessary for the repair of damaged tissues in the body.The fundamental problem in individuals experiencing hair loss is that hair follicles do not receive sufficient growth signals and enter a thinning process called "miniaturization." PRP aims to reverse this process at the cellular level. As an "autologous" treatment derived from the patient's own tissue, PRP carries no risk of allergic reaction or tissue rejection. This makes it one of the most reliable and effective medical methods in modern aesthetic surgery. When correct centrifuge techniques and activation processes are used, the effectiveness of PRP is maximized.
Biochemical Effects of PRP on Hair Roots
Platelets release proteins through degranulation in the area where they are injected. This process triggers critical mechanisms to wake dormant hair follicles and thicken existing hair strands:
- VEGF (Vascular Endothelial Growth Factor): Stimulates the formation of microscopic vessels that nourish hair follicles. As vascularization increases, the amount of oxygen and nutrients reaching the follicle rises.
- PDGF (Platelet-Derived Growth Factor): Promotes cell proliferation and accelerates the transition of follicles from the resting phase (telogen) to the active growth phase (anagen).
- EGF (Epidermal Growth Factor): Strengthens the matrix where the follicle is attached by accelerating collagen synthesis and cell metabolism in the scalp.
- FGF (Fibroblast Growth Factor): Stabilizes the hair life cycle and prevents early shedding by activating repair mechanisms of fundamental cells in the tissue.The synergistic effect of these growth factors not only stops shedding but also ensures existing hair appears brighter, more vibrant, and resilient. PRP is an indispensable repair protocol, especially for scalps exposed to chemical processes or weakened by sun damage. Cytokines within the plasma create an optimized environment for follicle health by reducing micro-inflammation in the scalp.
Hair Mesotherapy: Cellular Level Nourishment and Tissue Restoration
Hair mesotherapy is a method of delivering components directly to the target point that hair follicles need to maintain their life cycle and produce healthy hair strands, but which the body cannot supply in sufficient quantities through systemic circulation (oral vitamins, tablets, etc.). Mesotherapy is the process of depositing the hair's biological "fuel" directly into the tissue and eliminates the risk of systemic side effects thanks to its local action. Used in different fields of medicine since the 1950s, this method is one of the most powerful supportive treatments in plastic surgery today.The micro-needling technique used during the mesotherapy process also triggers the tissue's self-healing mechanism (wound healing response) by opening controlled micro-channels on the skin. This creates a mechanical revitalization in addition to the biochemical effect of the treatment. Mesotherapy provides holistic healing, especially for patients with scalp problems (dryness, oil imbalance) accompanying hair loss.
Pharmacological Content of Mesotherapy Cocktails
In our applications, personalized cocktails are preferred according to the patient's hair type, severity of loss, and scalp oil (sebum) balance. Key active substances in these contents include:
- Biotin and B Complex Vitamins: Increase mechanical resistance and shine of hair strands by boosting the production of keratin, the main building block of hair.
- Amino Acids (L-Cysteine, Methionine): Directly support protein synthesis necessary for the structural integrity and growth rate of hair.
- Zinc and Magnesium: Suppress inflammatory processes that trigger shedding by regulating enzyme activities.
- Copper Peptides: Ensure hair thickening by reducing the effect of hormones that cause follicle shrinking (miniaturization).
- Hyaluronic Acid: Maintains the moisture balance of the scalp, providing a healthy foundation by preventing dryness-related itching.
The mesotherapy solutions used in our clinic are world-standard approved, bio-compatible, and high-purity products. Each session offers a dynamic treatment process that can be revised according to the current needs of the hair.
Treatment Combinations: Why Should PRP and Mesotherapy Be Applied Together?
From a plastic surgery perspective, hair treatment is like conducting an orchestra. Scientific data shows that when the cell-triggering (stimulant) effect of PRP is combined with the raw material-providing (nutritional) effect of Mesotherapy, it creates a synergistic result. While PRP sends signals to the follicle cell to divide and grow, Mesotherapy leaves the building blocks necessary for this growth right next to the cell. This double effect multiplies the efficiency obtained from the treatment.
This combined approach can postpone the need for hair transplant surgery for years, especially in individuals at the beginning of genetic hair loss. By increasing the density of existing hair, it provides a fuller and more aesthetic appearance. Furthermore, this combination is the gold standard for increasing the retention rate of transplanted grafts in patients who have undergone hair transplant surgery.
Treatment Schedule and Clinical Outcome Expectations
Hair treatments are processes that require patience and depend on biological timing. The stimulation of a hair follicle and the emergence of a new hair strand on the skin surface biologically cover about 3-4 months. Protocols in our clinic generally yield results in these three phases:
- Month 1 (Stabilization): Visible slowing in the rate of active hair loss and establishment of oil/moisture balance in the scalp.
- Month 3 (Revitalization): Thickening of existing hair strands, increased shine, and emergence of new micro hairs (vellus hair).
- Month 6 and Beyond (Optimization): Noticeable increase in hair volume and complete stabilization of hair loss.
It should be noted that biological results may vary from person to person. Factors such as your metabolic rate, nutritional habits, and sleep patterns are secondary elements that support the success of the treatment. Our specialist physician monitors your progress throughout the process and updates the schedule if necessary.